Zubsolv

(ZUB-solv)

Zubsolv®️ is a combination medication containing buprenorphine, a partial opioid agonist, and naloxone, an opioid antagonist. It is used as a medication for addiction treatment (MAT) for opioid use disorder (OUD) to alleviate withdrawal symptoms and reduce cravings. Buprenorphine helps to suppress withdrawal symptoms, while naloxone deters misuse by precipitating withdrawal if the medication is injected.

Historical context

Zubsolv was approved by the FDA in 2013 as an alternative to other buprenorphine/naloxone medications like Suboxone®️. Its unique formulation allows for faster dissolution and improved bioavailability, offering another option for patients and healthcare providers in MAT for OUD.

Medical formulations

Zubsolv is available as sublingual tablets.

How long does Zubsolv stay in your system?

Zubsolv is a combination medication containing buprenorphine and naloxone, similar to Suboxone. The half-life of buprenorphine in Zubsolv is approximately 24 to 42 hours, while the half-life of naloxone is approximately 1 to 1.5 hours. It takes roughly 120 to 210 hours for buprenorphine and 5 to 7.5 hours for naloxone to be completely eliminated from the body.

Street names 

Zubs, Zolv

Appearance

Zubsolv is a sublingual tablet that generally has a white, round appearance. The tablet is imprinted with "OM" on one side and the dosage amount on the other side. The tablet dissolves under the tongue and has a menthol flavor.

Common pills

• Zubsolv®️ sublingual tablet (1.4 mg buprenorphine/0.36 mg naloxone): The tablet is white, round, and has "OM" on one side and "1.4" on the other side.
• Zubsolv®️ sublingual tablet (2.9 mg buprenorphine/0.71 mg naloxone): The tablet is white, round, and has "OM" on one side and "2.9" on the other side.
• Zubsolv®️ sublingual tablet (5.7 mg buprenorphine/1.4 mg naloxone): The tablet is white, round, and has "OM" on one side and "5.7" on the other side.