Zubsolv®: The “other” Suboxone®?

Discover the benefits and risks of Zubsolv®, a medication used to treat opioid addiction that has the same ingredients as Suboxone®. Learn how the two compare.

Ophelia team
Zubsolv® vs. Suboxone®
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Fact checked by
Arthur Robin Williams, MD

Opioid dependence is a growing concern in many countries, with millions of people affected by this condition. Medication-assisted treatment (MAT), is the gold-standard of care for those dependent on opioids. But you might be surprised to know that there are several medications on the market to help treat opioid use disorder (OUD). While informally known as “Subs” or “Bupe”, Zubsolv® and Suboxone® (important safety information) are both brand name drugs that combine buprenorphine and naloxone to treat opioid addiction. Yes, that means they contain the same ingredients, much like both Motrin® and Advil® both contain ibuprofen.

Much like Suboxone, Zubsolv is a FDA-approved prescription medication used to help people overcome opioid dependence and withdrawal symptoms. It is a sublingual tablet that dissolves under the tongue, delivering the active ingredients directly into the bloodstream. In this article, we will discuss the uses of Zubsolv, its side effects, and how it compares to similar medications, to help you understand the benefits and risks associated with this treatment option.

Uses of Zubsolv

Zubsolv contains two active ingredients: buprenorphine and naloxone. Buprenorphine is a partial opioid agonist, which means it activates the same receptors in the brain as opioids but to a lesser extent. This helps to reduce cravings and prevent withdrawal symptoms. Naloxone is an opioid antagonist, which means it blocks the effects of opioids. This helps to reduce the risk of abuse and misuse.

Zubsolv works by reducing cravings and minimizing withdrawal symptoms, making it easier for people to stick to their recovery plan. It is important to note that Zubsolv should only be used as part of a comprehensive treatment program, which may include behavioral therapy, support groups, and other medications. This combination of treatments has been shown to be effective in helping people overcome opioid dependence and achieve long-term recovery.

Side effects of Zubsolv

Like any medication, Zubsolv can cause side effects. Some of the most common side effects include nausea, headaches, constipation, sexual side effects, and sweating. In some cases, people may also experience more serious side effects, such as allergic reactions, changes in heart rate, or breathing problems. If you experience any side effects while taking Zubsolv, it is important to speak to your doctor as soon as possible.

It is also important to be aware of the potential for abuse and misuse of Zubsolv. The medication contains naloxone, which is designed to reduce the risk of abuse. However, it is still possible to misuse Zubsolv, and people who have a history of substance use disorders should have regular check ins with a clinician while taking this medication.

Comparison with similar medications

Zubsolv is one of several medications used for the treatment of opioid use disorder, including Suboxone, and methadone. When comparing Zubsolv to these other medications, it is important to consider factors such as the onset and duration of action, the potential for abuse, and side effect profile.

Onset and duration of Zubsolv, Suboxone, and Methadone
Onset and duration of three medications used to treat OUD.

Zubsolv is unique in that it is formulated with a quick onset of action and a duration of up to 24 hours, making it a convenient option for many people. In comparison, Suboxone has a slower onset of action but potentially a longer duration of up to 36 hours, while Methadone has an onset of action of several hours and a duration of up to 48-60 hours. Zubsolv’s ability to be quickly absorbed by the body, also known as its bioavailability, means that it is slightly more potent than Suboxone when taken at the same dosage.

The choice of medication will depend on your specific needs and medical history, and it is important to work closely with your doctor to determine the best option for you. In general, all of these medications have been shown to be effective in treating opioid use disorder and reducing the risk of relapse. Studies have shown that buprenorphine-based medications, like Zubsolv, are effective in reducing opioid use, improving patient outcomes, and improving quality of life. However, for some people also adding support and behavioral therapy are crucial for achieving long-term recovery.

Zubsolv is a valuable tool in the treatment of opioid use disorder, offering a quick onset of action, a duration of up to 24 hours, and a reduced risk of abuse. However, as with any medication, there are potential side effects, and it is important to work closely with your doctor to determine the best treatment plan for you. Additionally, MAT should be used as part of a comprehensive program that includes behavioral therapy, support groups, and other treatments as needed. By working with your healthcare team and committing to a long-term recovery plan, you can overcome opioid dependence and achieve a healthier, substance-free life.

MAT with Zubsolv

If eligible, you can receive either a Suboxone or Zubsolv prescription at Ophelia, accompanied by a customized treatment plan that fits privately into your life. Manage opioid dependence from the comfort of your home. Get started today by scheduling a free consultation call.


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