What is oxycodone?


Oxycodone is a semi-synthetic opioid derived from thebaine, an opium alkaloid, and is used to treat moderate to severe pain.

Historical context

Oxycodone was first synthesized in 1916 by German scientists Martin Freund and Edmund Speyer and gained widespread use in the 20th century.

Medical formulations

Oxycodone is available in immediate-release and extended-release formulations, both as a single-agent (e.g., OxyContin®️, Roxicodone®️) and in combination with other analgesics, such as acetaminophen (e.g., Percocet®️) or aspirin (e.g., Percodan®️).

How long does oxycodone stay in your system?

Oxycodone has a half-life of around 3 to 5 hours. It takes approximately 15 to 25 hours for the drug to be completely eliminated from the body.

Street names

Oxy, OC, OxyCotton, Hillbilly Heroin, Blues, Roxies


Oxycodone pills come in various shapes, sizes, and colors, depending on the manufacturer and dosage. They may be round, oblong, or capsule-shaped and can be white, blue, or green. Pills may be imprinted with the dosage and the manufacturer's logo.

Common pills

  • Round, white pill with "512" imprinted on one side and a score on the other side (5 mg with acetaminophen 325 mg)
  • Round, blue pill with "A 215" imprinted on one side (30 mg tablet)
  • Round, green pill with "A 214" imprinted on one side (15 mg tablet)

Warning: Consuming illicit drugs, including pressed pills, may result in unintended fentanyl exposure, leading to potentially fatal consequences. Exercise caution and consider using fentanyl testing strips to identify the presence of this dangerous substance in street drugs.

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