What is tolerance?

Tolerance is a phenomenon in which a person needs increasing amounts of a substance to achieve the desired effects or experiences diminished effects with the same amount of the substance. Tolerance can develop with regular use of a substance and is a significant factor in the development of substance use disorders.


Opioid tolerance can lead to increased dosages and higher risk of overdose. Tolerance can also contribute to the development of opioid use disorder (OUD) and complicate the treatment process.

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