What is methadone?


Methadone is a synthetic opioid used primarily in the treatment of opioid addiction, as it helps to alleviate withdrawal symptoms and reduce cravings. It is also used to treat chronic pain.

Historical context

Methadone was first synthesized in 1937 by German scientists Max Bockmühl and Gustav Ehrhart. It was introduced in the United States in the 1940s and gained prominence as a treatment for opioid addiction in the 1960s.

Medical formulations

Methadone is available in oral tablets, oral solutions, and injectable forms. It is usually administered in specialized clinics under strict supervision.

How long does methadone stay in your system?

Methadone has a half-life of about 8 to 59 hours, with an average of around 24 hours. It takes approximately 40 to 295 hours for the drug to be completely eliminated from the body.

Street names

Meth, Dollies, Dolls, Done, Juice


Methadone pills are typically round or oblong and come in various colors, such as white, orange, or green, depending on the formulation and dosage. They may be imprinted with the dosage and the manufacturer's logo.

Common pills

  • Round, white pill with "54 142" imprinted on one side and a score on the other side (10 mg tablet)
  • Round, orange pill with "54 225" imprinted on one side (40 mg tablet)
  • Round, white pill with "M" in a square on one side and "10" on the other side (10 mg tablet)
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