Hydrocodone

(hye-droh-KOH-dohn)

What is hydrocodone?

Hydrocodone is a semi-synthetic opioid derived from codeine and is used to treat moderate to severe pain and cough.

Historical context

Hydrocodone was first synthesized in 1920 by German chemists Carl Mannich and Helene Löwenheim and gained popularity in the United States in the 1950s.

Medical formulations

Hydrocodone is available in combination with non-opioid analgesics, such as acetaminophen (e.g., Vicodin®️, Lortab®️, Norco®️) or ibuprofen (e.g., Vicoprofen®️).

How long does hydrocodone stay in the body?

Hydrocodone has a half-life of about 3.5 to 4.5 hours. It takes roughly 18 to 22.5 hours for the drug to be completely eliminated from the body.

Street names

Vike, Watson, Norco

Appearance

Hydrocodone combination pills vary in shape, size, and color, depending on the manufacturer and dosage. They may be round, oblong, or capsule-shaped and can be white, yellow, or orange. Pills may be imprinted with the dosage and the manufacturer's logo.

Common pills

  • White, oval pill with "M365" imprinted on one side (5 mg with acetaminophen 325 mg)
  • White, oblong pill with "M367" imprinted on one side (10 mg with acetaminophen 325 mg)
  • White, oblong pill with "L484" imprinted on one side (7.5 mg with acetaminophen 500 mg)

Warning: Consuming illicit drugs, including pressed pills, may result in unintended fentanyl exposure, leading to potentially fatal consequences. Exercise caution and consider using fentanyl testing strips to identify the presence of this dangerous substance in street drugs.

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